魏雪濤

免疫毒理學

分子與細胞毒理學

環境汙染物

藥物毒理

生物活性物質的免疫調節作用

安全性評價和風險評估

1. 科技創新2030-重大專項 生物育種產品食用毒理學關鍵問題研究及評價新技術研發

2. 國家重點研發計劃 基因編輯產品食用與環境安全評價新技術和模型創製

3. 國家自然科學基金  老化黑碳所致呼吸道炎症中的鐵蛋白——IL-33相關毒性作用通路研究

4. 國家重點研發計劃“基於毒作用機製和健康效應終點的食品稀土元素和添加劑的安全性評估”

5. 國家科技支撐項目“男用避孕方法的研究——LTQ藥物抗生育作用過程中相關毒理研究”

6. 國家自然科學基金重大項目“二次顆粒物和臭氧的環境暴露和健康效應”

1. Yuan Cui, Qianqian Xiao, Qiong Zhang, Jiawei Yang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes. J Hazard Mater. 2024 Oct 5:478:135375.

2. Yuese Yuan, Yimeng Zhuang, Yuan Cui, Yuetong Liu, Qiong Zhang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats. Toxicol Appl Pharmacol. 2024 Sep: 490: 117020.

3. Yuan Cui, Qianqian Xiao, Zhenyu Wang, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine. J Hazard Mater. 2024 Jan 5:461:132597.

4. Yuese Yuan, Yimeng Zhuang, Yuan Cui, Yuetong Liu, Qiong Zhang, Qianqian Xiao, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. IL-10-TG/TPO-T4 axis, the target of bis (2-ethylhexyl) tetrabromophthalate on thyroid function imbalance. Toxicology. 2024 Jan:501:153713.

5. Qiong Zhang, Zhenyu Wang, Qianqian Xiao, Jianhong Ge, Xiaoyun Wang, Wanyu Jiang, Yuese Yuan, Yimeng Zhuang, Qinghe Meng, Jianjun Jiang, Weidong Hao, Xuetao Wei*. The effects and mechanisms of the new brominated flame retardant BTBPE on thyroid toxicity. Food Chem Toxicol. 2023 Oct:180:114027.

6. Yuan Cui, Qianqian Xiao, Qiong Zhang, Yuetong Liu, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. Black carbon nanoparticles activate the crosstalk mechanism betweennecroptosis and macrophage extracellular traps to change macrophages fate. Environ Res. 2023 Sep 1;232:116321. 

7. Yuan Cui, Qianqian Xiao, Yuese Yuan, Yimeng Zhuang, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. Ozone-oxidized black carbon particles change macrophage fate: Crosstalk between necroptosis and macrophage extracellular traps. Environ Pollut. 2023; 329:121655.

8. Yuan Cui, Qianqian Xiao, Yuese Yuan, Yimeng Zhuang, Weidong Hao, Jianjun Jiang, Qinghe Meng, Xuetao Wei*. 1,4-Naphthoquinone-Coated Black Carbon, a Kind of Atmospheric Fine Particulate Matter, Affects Macrophage Fate: New Insights into Crosstalk between Necroptosis and Macrophage Extracellular Traps. Environ Sci Technol. 2023 Apr 18;57(15):6095-6107.

9. Zekang Li, Wanyu Jiang, Hongqian Chu, Jianhong Ge, Xiaoyun Wang, Jianjun Jiang, Qianqian Xiao, Qinghe Meng, Weidong Hao, Xuetao Wei* Exploration of potential mechanism of interleukin-33 up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7 cells. Sci Total Environ. 2022, 835:155357.

10. Jianhong Ge, Hongqian Chu, Qianqian Xiao, Weidong Hao, Jing Shang, Tong Zhu, Zhaogang Sun, Xuetao Wei*. BC and 1,4NQ-BC up-regulate the cytokines and enhance IL-33 expression in LPS pretreatment of human bronchial epithelial cells. Environ Pollut. 2021, 273:116452